Adult Open Studies

Biology

LLUCC-BIOSPECIMEN LABORATORY - SPECIMEN COLLECTION
Loma Linda University Cancer Center Biospecimen Laboratory Specimen Collection Protocol

Champions Oncology
Refer to separate attachment for list of "Tumors of High Interest"; this is included within the LLUCC Biospecimen Laboratory study above

Breast

SWOG-S2007
A Phase II Trial of Sacituzumab Govitecan for Patients with HER2-Negative Breast Cancer and Brain Metastases
https://www.clinicaltrials.gov/ct2/show/NCT04647916

Syndevrx SDX-0103
A Phase 1b/2 Study Assessing The Safety And Efficacy of Evexomostat (Sdx-7320) In Combination With The Pi3kα Inhibitor alpelisib (Piqray®) Plus Fulvestrant In Postmenopausal Women At Risk For Hyperglycemia With Advanced Breast Cancer And A Pik3ca Mutation Who Have Progressed On Or Following Endocrine Therapy Plus A Cdk4/6 Inhibitor

EMBER-4 E-Lilly – J2J-MC-JZLH
A Randomized, Open Label, Phase 3 Study of Adjuvant imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients who have previously received 2 to 5 years of Adjuvant Endocrine Therapy for ER+, HER2-Early Breast Cancer with an Increased Risk of Recurrence.
https://classic.clinicaltrials.gov/ct2/show/NCT05514054

SWOG -S2212
Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast (SCARLET), A Randomized Phase III Study  
https://classic.clinicaltrials.gov/ct2/show/NCT05929768

COVID-19

Statera BioPharma-ST205-101-002
Randomized, Single-Blind Study to Evaluate the Pharmacokinetics, Biomarkers, Safety and Tolerability of STAT-205 in Adult Patients with Mild COVID 19 Who Are at High Risk of Disease Progression
https://clinicaltrials.gov/ct2/show/NCT04708327
 

Germ Cell

SWOG-S1823
A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors https://clinicaltrials.gov/ct2/show/NCT04435756

GI

Esophageal

Radiation Medicine
A phase II trial of proton-chemotherapy (PCT) for resectable esophageal or esophagogastric junction cancer
https://clinicaltrials.gov/ct2/show/NCT01684904

Pancreas

INV INT-Pancreatic - 5170277
A Phase II Trial of Pre-operative Chemotherapy (with Gemcitabine and Nab-paclitaxel) and Stereotactic Body Radiotherapy Followed by Surgery and Chemotherapy in Patients with Resectable Pancreatic Adenocarcinoma
https://www.clinicaltrials.gov/ct2/show/NCT03492671

Liver

Radiation Medicine
Phase I/II Trial of Stereotactic Body Proton Therapy (SBPT) for Patients with Liver Metastases 
https://clinicaltrials.gov/ct2/show/NCT01697371

Colon

Penn State-Colon Registry - 5180134
Prospective observational database of patients with colon cancer at risk of peritoneal recurrence

GU

Prostate

RADIATION MEDICINE
A prospective comparative study of outcomes with proton and photon radiation in prostate cancer (COMPPARE)

GYN

Ovarian/ Peritoneum

SWOG-NRG-GY019
A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum
https://www.clinicaltrials.gov/ct2/show/NCT04095364

Lung

ALLIANCE-A151216
Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
https://clinicaltrials.gov/ct2/show/NCT02194738

NSCLC

ECOG-ACRIN-E4512
A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein
https://clinicaltrials.gov/ct2/show/NCT02201992

NSCLC

SWOG-S1914
A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC
https://clinicaltrials.gov/ct2/show/NCT04214262

NSCLC

SWOG-LUNGMAP
A Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer
https://www.clinicaltrials.gov/ct2/show/NCT02154490

LS-SCLC

Merck-MK-7339-013-02
A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib (MK-7339), Compared to Concurrent Chemoradiation Therapy Alone in Participants with Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC)
https://clinicaltrials.gov/ct2/show/NCT04624204

NSCLC

SWOG-A081801
Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO
https://clinicaltrials.gov/ct2/show/NCT04267848

NSCLC

SWOG-S2302
Summary: A Prospective Randomized Study of Ramucirumab (LY3009806: NSC#783608 + SBRT versus SBRT alone in High Risk, Early Stage NSCLC  https://clinicaltrials.gov/study/NCT05633602  

Melanoma

Castle Biosciences-CBI-2019-SLNBprosp-001
DecisionDx-Melanoma Impact on Sentinel Lymph Node Biopsy Decisions and Clinical Outcomes DECIDE
https://clinicaltrials.gov/ct2/show/NCT02355587

Multiple

COG-AGCT1532
A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with Intermediate and poor-risk metastatic germ cell tumors (Ages 26+ - Primary tumor arising in testis, ovary, retro-peritoneum or mediastinum)

Solid Tumors

Apollomics-APL-101-01
Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

AMGEN-20190135-H
A Phase 1b Study Evaluating the Safety, Tolerability and Efficacy of AMG 510 (pINN Sotorasib) in Combination with Panitumumab and FOLFIRI in Subjects with Advanced Solid Tumors with KRAS p.G12C Mutation (Codebreak 101 Subprotocol H)
https://clinicaltrials.gov/study/NCT04185883

Transplant

PTLD

ATARA - ATA129-EBV-302
Multicenter, Open Label, Phase 3 Study of Tabelecleucel for Solid Organ Transplant Subjects with Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease after Failure of Rituximab or Rituximab and Chemotherapy (ALLELE Study)
https://clinicaltrials.gov/ct2/show/NCT03394365