Adult Open Studies

Biology

LLUCC-BIOSPECIMEN LABORATORY - SPECIMEN COLLECTION
Loma Linda University Cancer Center Biospecimen Laboratory Specimen Collection Protocol

Brain

SWOG-NRG-BN001
Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastom
https://clinicaltrials.gov/ct2/show/NCT02179086
SWOG-A221101
A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with High Grade Glioma
https://clinicaltrials.gov/ct2/show/NCT01781468
SWOG-EAF151
Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma
https://clinicaltrials.gov/ct2/show/NCT03115333

Breast

NSABP-B51
A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
https://clinicaltrials.gov/ct2/show/NCT01872975
NSABP-B58
A Randomized, Open-Label, Phase 3 Study of Abemaciclib combined with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative Breast Cancer
https://clinicaltrials.gov/ct2/show/NCT03155997
SWOG-A011106
ALTernate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant TrEatment (ALTERNATE) in postmenopausal women: A Phase III Study
https://clinicaltrials.gov/ct2/show/NCT01953588
SWOG-A011202
A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy.
https://clinicaltrials.gov/ct2/show/NCT01901094
SWOG-S1207
Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of EVEROLIMUS in Patients with High-Risk Hormone Receptor-Positive and HER2/neu Negative Breast Cancer.
http://www.clinicaltrials.gov/ct2/show/NCT01674140
Investigator Initiated GRASP-CIPN
A Pilot Study of Intraneural Facilitation for Managing Chemotherapy-Induced Peripheral Neuropathy.
https://clinicaltrials.gov/ct2/show/NCT03272919
SWOG-S1418-BR006
A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 as Adjuvant Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Cancer.
https://clinicaltrials.gov/ct2/show/NCT02954874

GI

Bowel

SWOG-S1316
Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction
https://clinicaltrials.gov/ct2/show/NCT02270450

Colon

SWOG-S0820
A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients with Stage 0-III Colon Cancer, Phase III - Preventing Adenomas of the Colon with Eflornithine and Sulindac (PACES)
https://www.clinicaltrials.gov/ct2/show/NCT01349881

Esophagus

Radiation Medicine
A phase II trial of proton-chemotherapy (PCT) for resectable esophageal or esophagogastric junction cancer
https://clinicaltrials.gov/ct2/show/NCT01684904

Gastric

Investigator Intiatied HIPEC
Adjuvant Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Gastric Cancer
https://clinicaltrials.gov/ct2/show/NCT02672865

Liver

Radiation Medicine
Phase I/II Trial of Stereotactic Body Proton Therapy (SBPT) for Patients with Liver Metastases
https://clinicaltrials.gov/ct2/show/NCT01697371

Pancreas

Radiation Medicine
A phase II trial of gemcitabine and erlotinib (GB) plus proton-chemotherapy (PCT) and capox for locally advanced pancreatic cancer (LAPC)
https://clinicaltrials.gov/ct2/show/NCT01683422

GU

Kidney / Urothelial

Urogen-TC-UT-03-P
A Phase 3 Multicenter Trial Evaluating the Efficacy and Safety of MitoGel™ on Ablation of Upper Urinary Tract Urothelial Carcinoma
https://clinicaltrials.gov/ct2/show/NCT02793128

Prostate

Radiation Medicine
Phase I-II trial of hypofractionated conformal proton beam radiation therapy for favorable-risk prostate Cancer
https://clinicaltrials.gov/ct2/show/NCT00831623
Radiation Medicine
Cytogenetic damage as a biomarker of radiation sensitivity in prostate cancer
Marcelo Vazquez , MD, PhD

Testicular

Investigator Initated-4T-14-1
Phase II Trials of Retroperitoneal Lymph Node Dissection as First-Line Treatment for Testicular Seminoma with Isolated Retroperitoneal Disease (1-2cm)
https://clinicaltrials.gov/ct2/show/NCT02537548

GYN

Multiple

Investigator Initated-Paclitaxel
Conventional prophylactic regimen of oral dexamethasone versus short-course intravenous dexamethasone in preventing paclitaxel-related hypersensitivity reactions in gynecologic-oncology patients: A prospective, randomized, open-label study
https://clinicaltrials.gov/ct2/show/NCT03598426

Ovarian

Investigator Initiated HIPEC
Hyperthermic Intraperitoneal Chemotherapy for Recurrent Ovarian Cancer
https://clinicaltrials.gov/ct2/show/NCT02672098

Uterus

GOG-0263
Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy
https://clinicaltrials.gov/ct2/show/NCT01101451
GOG-0238
A Randomized Trial Of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin In Patients With Pelvic-Only Recurrence Of Carcinoma Of The Uterine Corpus
https://clinicaltrials.gov/ct2/show/NCT00492778

Lung

SWOG-A151216
Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
https://clinicaltrials.gov/ct2/show/NCT02194738
SWOG-A081105
Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)
https://clinicaltrials.gov/ct2/show/NCT02194738
SWOG-EA5142
Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers
https://clinicaltrials.gov/ct2/show/NCT02595944
SWOG-E4512
A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein
https://clinicaltrials.gov/ct2/show/NCT02201992
SWOG-S1400
Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer
https://clinicaltrials.gov/ct2/show/NCT02154490
Pfizer-B7461020
An expanded access protocol for Lorlatinib for treatment of patients with advanced non-small cell lung cancer harboring specific molecular alterations
https://clinicaltrials.gov/ct2/show/NCT03178071

Lymphoma

SWOG-S1609
Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma
https://clinicaltrials.gov/ct2/show/NCT03269669
SWOG-S1608
Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma
https://clinicaltrials.gov/ct2/show/NCT03269669

Multiple

SWOG-EAY131-MATCH
Molecular Analysis for Therapy Choice (MATCH)
https://clinicaltrials.gov/ct2/show/NCT02465060
SWOG-S1609
DART: Dual Anti-CTLA-4 and Anti-PD-1 blockade in Rare Tumors
https://clinicaltrials.gov/ct2/show/NCT02834013

Soft Tissue Sarcoma

SWOG-A091401
Randomized Phase II Study of Nivolumab with or without Ipilimumab in Patients with Metastatic or Unresectable Sarcoma
https://clinicaltrials.gov/ct2/show/NCT02500797
Radiation Medicine
A phase II study of preoperative proton therapy in soft tissue sarcomas of the extremities and body wall
https://clinicaltrials.gov/ct2/show/NCT01819831

Registry

Radiation Medicine
Radiation Medicine Patient Registry
https://clinicaltrials.gov/ct2/show/NCT02436941