Currently Enrolling Clinical Trials

End Stage Macular Degeneration

  • VisionCare Ophthalmic Technologies, Inc.: IMT - PAS (for Phakic Eyes): A Prospective, Multicenter Post-Approval Study (PAS) of VisionCare’s Implantable Miniature Telescope (By Dr. Isaac Lipshitz) in Patients with Bilateral Severe to Profound Central Vision Impairment Associated with End-stage Age-Related Macular Degeneration.
     
    Inclusion Exclusion IMT PAS
  • VisionCare Ophthalmic Technologies, Inc.: IMT - TES (for Pseudophakic Eyes): A Prospective, Multicenter Clinical Trial of the Implantable Miniature Telescope in Pseudophakic Eyes With Central Vision Impairment Associated With End-Stage Macular Degeneration.
     
    Inclusion Exclusion IMT TES
     
    Principal Investigator: Michael E. Rauser, MD
    For more information on VisionCare IMT PAS and TES, please contact: measterly@llu.edu or OphthalmologyResearch@llu.edu

DIABETIC Retinopathy

  • DRCR - Genetics in Retinal Diseases Project: Genes in Diabetic Retinopathy Project .The goal of this project is to create a repository of at least 5000 participant’s blood samples with 114 extracted genetic material and clinical phenotype information as a resource for the research 115 community, both public and private institutions.
     
    Principal Investigator: Joseph T. Fan, MD
     
  • DRCR - Protocol AC: Randomized Trial of Intravitreous Aflibercept versus Intravitreous Bevacizumab + Deferred Aflibercept for Treatment of Central-Involved Diabetic Macular Edema.
    Inclusion Exclusion Protocol AC
     
    Principal Investigator: David Sierpina, MD
    For more information on DRCR, please contact: RaqHernandez@llu.edu or OphthalmologyResearch@llu.edu

NAION

  • Quark - QRK207: A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered by Single or Multi-Dose Intravitreal Injection(s) to Subjects with Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
     
    Inclusion Exclusion NAION
     
    Principal Investigator: Michael E. Rauser, MD
    For more information on NAION, please contact: TIRamirez@llu.edu or OphthalmologyResearch@llu.edu

NEI -ZEDS

  • The National Eye Institute, Zoster Eye Disease Study (ZEDS) – Zoster Eye Disease Study (ZEDS): A multi-center, randomized, double-masked, placebo-controlled clinical trial of valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment. Expected start date of November 2017.
     
    Inclusion Exclusion ZED  |  ZED Poster  |  ZED Brochure |  ZED Recruitment
     
    Principal Investigator: Frank Hwang, MD
    For more information on Zoster Eye Disease, please contact: TIRamirez@llu.edu or OphthalmologyResearch@llu.edu

PEDiatric studies

  • PEDIG ATS20: Amblyopia Treatment study (ATS20) Binocular Dig Rush Game Treatment for Amblyopia. The main objective is to compare the efficacy of 1 hour/day of binocular game play 5 days per week plus spectacle correction with spectacle correction only, for treatment of amblyopia in children 4 to 13 years of age.
     
    Inclusion Exclusion ATS20
     
    Principal Investigator: Timothy Winter, DO
    For more information on Pediatric studies, please contact: Measterly@llu.edu or OphthalmologyResearch@llu.edu

Conjuctivitis

  • Shire: SHP640 301: A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension
    Compared to PVP-Iodine and Placebo in the Treatment of Adenoviral Conjunctivitis.
     
    Inclusion Exclusion SHIRE
     
    Principal Investigator: John Affeldt, MD
    For more information on Conjunctivitis - Shire, please contact: measterly@llu.edu or OphthalmologyResearch@llu.edu

VMT & MH

  • DRCR - Protocol AG: Randomized Clinical Trial Assessing the Effects of PneumaticVitreolysis on Vitreomacular Traction.
  • DRCR - Protocol AH: Pneumatic Vitreolysis (PVL) with Gas for Macular Hole (MH) single-arm study.

Principal Investigator: Samuel Kim, MD
For more information on DRCR and Protocol AG and DRCR Protocol AH, please contact: TIRamirez@llu.edu or OphthalmologyResearch@llu.edu

Future Clinical Trials

Santen LUMINA : A Phase III, Multicenter, Sham-Controlled, Randomized, Double-Masked Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 μg DE-109 for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye.

Expected April 2019

Principal Investigator: Michael E. Rauser, MD

Graybug GBV-102-002: A Phase 2 Multicenter Dose-Ranging Study Evaluating the Safety and Efficacy of a Long-acting Intravitreal Sunitinib Malate Depot Formulation (GB-102) Compared to Intravitreal Aflibercept in Subjects with Neovascular (Wet) Age-related Macular Degeneration (PRELUDE Study)

Expected June 2019

Principal Investigator: Samuel C. Kim, MD

Allergan - AGN-190584: A Phase 3, Multicenter, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety and Efficacy of AGN-190584 in Participants with Presbyopia

Expected June 2019

Principal Investigator: David I. Sierpina, MD

Loma Linda University Eye Institute Research Division

If you would like to know if you qualify for our Clinical Trials, Please call us at 909-558-2168 / OphthalmologyResearch@llu.edu