We continue to have a strong commitment to medical research and the advancement of treatments for all conditions of eye diseases. If you or someone you know is interested in more information about our clinical research trials in Ophthalmology, please call 909-558-2233 or email the research coordinators Marcia Easterly, Tina Ramirez and Raquel Hernandez.
Current Clinical Trials
AGE-RELATED MACULAR DEGENERATION STUDIES
Graybug GBV-102-002: A Phase 2 Multicenter Dose-Ranging Study Evaluating the Safety and Efficacy of a Long-acting Intravitreal Sunitinib Malate Depot Formulation (GB-102) Compared to Intravitreal Aflibercept in Subjects with Neovascular (Wet) Age-related Macular Degeneration.
A 12- month study.
VisionCare Ophthalmic Technologies, Inc.: IMT - PAS (for Phakic Eyes): A Prospective, Multicenter Post-Approval Study (PAS) of VisionCare’s Implantable Miniature Telescope (By Dr. Isaac Lipshitz) in Patients with Bilateral Severe to Profound Central Vision Impairment Associated with End-stage Age-Related Macular Degeneration.
A 5-year study.
VisionCare Ophthalmic Technologies, Inc.: IMT - TES (for Pseudophakic Eyes): A Prospective, Multicenter Clinical Trial of the Implantable Miniature Telescope in Pseudophakic Eyes With Central Vision Impairment Associated With End-Stage Macular Degeneration.
A 3-year study.
Principal Investigator: Michael Rauser, MD
Please contact Marcia Easterly at MEasterly@llu.edu or 909-558-2233 ex. 22732.
Novartis-TALON study: A two-arm, randomized, double-masked, multi-center, phase lllb study assessing the efficacy and safety of brolucizumab 6 mg compared to aflibercept 2 mg in a treat-to-control regimen in patients with neovascular age-related macular degeneration.
A 64-week study.
Principal Investigator: Michael Rauser, MD
Please contact Tina Ramirez at TIRamirez@llu.edu or 909-558-2233 ex. 22230.
DIABETIC STUDIES
DRCR - Genetics in Retinal Diseases Project: Genes in Diabetic Retinopathy Project .The goal of this project is to create a repository of at least 5000 participant’s blood samples with 114 extracted genetic material and clinical phenotype information as a resource for the research 115 communities, both public and private institutions.
Principal Investigator: David Sierpina, MD
Please contact Tina Ramirez at TIRamirez@llu.edu or 909-558-2233 ex. 22230.
HERPES ZOSTER STUDIES
The National Eye Institute, Zoster Eye Disease Study (ZEDS) – Zoster Eye Disease Study (ZEDS): A multi-center, randomized, double-masked, placebo-controlled clinical trial of valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment.
A 18-month study.
Principal Investigator: Frank Hwang, MD
Please contact Tina Ramirez at TIRamirez@llu.edu or 909-558-2233 ex. 22230.
DIABETIC MACULAR EDEMA STUDIES
Novartis CRTH258B2305 KINGFISHER: This is a 2-Arm, Randomized, Double-Masked, Multicenter Phase III Study Assessing the Efficacy and Safety of Brolucizumab every 4 weeks versus Aflibercept every 4 weeks in Adult Patients with Visual Impairment due to Diabetic Macular Edema.
A 12-month study.
Principal Investigator: Michael Rauser, MD
Please contact Tina Ramirez at TIRamirez@llu.edu or 909-558-2233 ex. 22230.
PEDIATRIC STUDIES
PEDIG ATS20: Amblyopia Treatment study (ATS20) Binocular Dig Rush Game Treatment for Amblyopia. The main objective is to compare the efficacy of 1 hour/day of binocular game play 5 days per week plus spectacle correction with spectacle correction only, for treatment of amblyopia in children 4 to 13 years of age.
A 16-week study.
PEDIG IXT6: A Pilot Randomized Clinical Trial of Base-in Prism Spectacles for Intermittent Exotropia
A 8-week study.
Principal Investigator: Timothy Winter, DO
Please contact Marcia Easterly at MEasterly@llu.edu or 909-558-2233 ex. 22732.
UVEITIS STUDIES
Santen LUMINA: A Phase III, Multicenter, Sham-Controlled, Randomized, Double-Masked Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 μg DE-109 for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye. A 12-month study.
Principal Investigator: Michael Rauser, MD
Please contact Marcia Easterly at MEasterly@llu.edu or 909-558-2233 ex. 22732.
VIRTUAL MACULAR TRACTION & MACULAR HOLE STUDIES
DRCR - Protocol AG: Randomized Clinical Trial Assessing the Effects of Pneumatic Vitreolysis on Vitreomacular Traction.
A 2-year study.
DRCR – Protocol AH: Single-Arm Study Assessing the Effects of Pneumatic Vitreolysis on Macular Hole.
A 2-year study.
Principal Investigator: Kakarla Chalam, MD
For more information on virtual macular traction and macular hole studies, please contact Ms. Tina Ramirez at TIRamirez@llu.edu or 909-558-2233 ex. 22230.